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The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy. Healthy volunteers were exposed to nanoparticles by acute inhalation, followed by repeated sampling of blood and urine.
Gold was detected in the blood and urine within 15 min to 24 h after exposure, and was still present 3 months after exposure. Levels were greater following inhalation of 5 nm (primary diameter) particles compared to 30 nm particles. Studies in mice demonstrated the accumulation in the blood and liver following pulmonary exposure to a broader size range of gold nanoparticles (2–200 nm primary diameter), with translocation markedly greater for particles.
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'In the beginning was the Word.' , then the Internet, and finally blockchain! Having combined all these steps together, we will get a revolutionary project - WORDCOIN! Global world changes, occurring due to blockchain technologies, are irreversible.
Smart contracts give the opportunity to outrun half of the players in the market who charge unwanted agent fees, making many services 60% cheaper, and save a lot of time. Currently, the total freelance market volume reaches $1 billion. Having combined the most popular services in the frames of one decentralized platform - Word.Expert (WE) with the sole cryptocurrency WORDCOIN - we will create a multiplier effect, which will cause the explosive growth in numbers of platform users, freelance services efficiency and WORDCOIN rate, which is limited in offer.
• Copywriting is one of the most demanded professions in the world as the most common way to store and transfer information is written data. All Internet records consist of symbols. Every website contains titles, phrases, specifications and different types of text. Millions of posts, reviews and articles are published daily. And text is the only source of information which is freely accepted by people and recognition algorithms of search engines. To keep its leading positions in Yandex and Google search results, the website shall be periodically updated with useful and unique content, filled with correct key words and should be kept attractive for its users.
99,9% of the websites we visit are created to attract an audience by regularly updating it with unique information. Because of this, the annual turnover of the present copywriting market reaches $1 trillion. • In terms of the current rapid-growth market, international connections between people and commercial enterprises are getting stronger. Entering an international market requires the development of global advertising campaigns, the translation of advertising products and websites. At the same time the document turnover increases a lot, so that translation services will be more in demand, and the long-standing request for further blurring the boundaries and decreasing transactional costs are limited only by the lack of an international user-friendly platform, which will give a new impulse for translation markets and increase its capacity from current $70 million to principally new amounts. The annual turnover of the translation market reaches $250 billion.
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